SimpleFold atteint 95% des performances d’AlphaFold2 tout en étant infiniment plus léger. En effet, AlphaFold nécessite des supercalculateurs avec des GPU à 20 000 balles pièce alors SimpleFold, lui tourne tranquille sur un MacBook Pro M2 avec 64GB de RAM.

Et c’est super cool parce que prédire la structure d’une protéine, c’est pas juste un truc de geek pour s’amuser. C’est LA base pour créer de nouveaux médicaments, comprendre des maladies, développer des vaccins… Jusqu’à présent, seuls les gros labos avec des budgets de malade pouvaient se permettre de faire ça, c’est pourquoi SimpleFold change complètement la donne en rendant cette technologie accessible à n’importe quel chercheur avec un MacBook.

Le document est disponible sur https://arxiv.org/abs/2509.18480

Je pose cela ici.

L'article complet est disponible sur https://archive.is/tAeLS

• 40 millions de joueurs de jeu vidéo en France.
• 88% sont des adultes.
• âge moyen : 40 ans.
• 49% sont des femmes.

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A red employee enjoys obeying the rules and climbs up the career ladder by making the boss happy. To the contrary, a black employee, while understanding the inevitability, despises the necessity to obey.

In any large organization, reds will always dominate—it’s inevitable. The system needs them, and they thrive inside it. [...] If you are black, don’t waste energy trying to convert or fight the reds. You won’t win. The only strategy is distance.

Moins d'argent dans la santé publique, et voici une étude qui confirme des décès plus élevé chez les 40% les moins favorisés.

In this study, the socioeconomic level of the mother's place of residence was strongly associated with the neonatal mortality rate. The data showed that inequalities have widened, contributing to the increase in the neonatal mortality rate.

It can be useful to rewrite git repositories.

What I do want to put the focus on, however, is that you have to perform an audit of your product every so often and see how the people using your product have changed, and what kind of functionality that made sense at the time may not make much sense anymore.

• load images automatically
• enable JS
• turn-off the navigation toolbar
• turning off SSL & TLS
• certificate manager
• override automatic cache management

The people that need to do these things should use add-ons, or at the very least an about:config tweak.

I would argue: it makes the configuration or preferences UI lightweight.

DocuSeal is an open source platform that provides secure and efficient digital document signing and processing. Create PDF forms to have them filled and signed online on any device with an easy-to-use, mobile-optimized web tool.

Un autre article sur la command z, aussi utilisé comme alias de cd

Aucune déclaration de succession n'est exigée quand le montant brut ne dépasse pas 50k €, et qu'un abattement de 100k s'applique sur le patrimoine transmis par chaque parent à chaque enfant.

En dehors des cas de gratuité, le décret plafonne les frais à 1% du montant total des soldes, dans la limite de 850 €. Même les petites successions verront donc baisser le coût d'une transmission.

La taxe sur les ordures ménagères (TOEM) doit uniquement servir à traiter les déchets actuellement.

When we look around in our field, everyone in Tech seems to focus on one thing: "How can we adopt AI in our tooling and in our processes?"

So it is a proof of a bubble. Everyone is enthusiasts but it doesn't solve real use cases.

A rightful question can be: "How can we set up our engineers for long-term career success?"

Jens Meiert ask pertinent questions to solve this big up question.

What can be done reasonably well with AI today? (And tomorrow? And the day after tomorrow?)
How are our engineers affected by AI?

• Are our engineers using AI?
• How are our engineers using AI?
• What are realistic expectations for our engineers in terms of AI use and proficiency?
• Are we setting clear expectations for use of and proficiency with AI in our job descriptions as well?
• Do we document and anchor these expectations in our competency and skill matrixes?
• Are we watching the AI market, and are we evaluating tooling?
• While the AI market is in flux—which it may be for some time—, do we have enough flexibility (budget, processes, room for errors) to test AI tooling?
• If our engineers leave the company, would they find a new job—or would their profile make them less interesting?
• If they would not necessarily find a new job, what extra skills and experience do they need?
• How can we make our engineers ready for the AI age?

As you can tell, we cannot have all those answers yet—this is precisely why this is so important to get on top of, and it’s also the reason why I say “start answering.”

• inline svgs
• named grid lines and areas
• scrollIntoView()
• position: sticky elements in CSS transforms

The list is huge actually! It shows how complex a web browser has become.

Now, everyone’s a prize exhibit in the FAANG zoo, because mastering this tangled mess is what opens their gates. Being just a CRUD monkey doesn’t feel fun anymore. If this is what “progress” looks like, I don’t want any part of it.

The technologies to build for 10 years ago dramatically improved!

As mentionned by LeHollandaisVolant, one thing the article doesn't mention is that:

• 1 the pages are more interactive
• 2 the data changes in real time

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